After contracting a serious ear, nose and throat infection while in Africa, Princess Charlene will not be able to return to Monaco in May for her 10th wedding anniversary.
The royal, 43, will instead have to undergo several procedures in her native South Africa as part of her treatment.
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Charlene has not returned to Monaco since January, but announced in June that her husband, Prince Albert, and their six-year-old twins, Princess Gabriella and Prince Jacques, had visited her in South Africa.
“This year will be the first time that I will not be with my husband for our anniversary in July, which is difficult and saddens me,” Princess Charlene said in a statement reported by the Daily Mail.
“However, Albert and I had no choice but to follow the instructions of the medical team even though it was extremely difficult. He has been the most incredible support for me.
“My daily conversations with Albert and my kids help me keep my spirits up a lot, but I miss being with them. It was special for my family to visit me in South Africa, and it was really wonderful to see them. I can’t wait to find them.
Princess Charlene first came to South Africa to do conservation and anti-poaching work earlier this year.
According to To post, her foundation says the royal drove business close to her heart and devoted herself entirely to projects when she fell ill.
Prior to contracting the infection, she worked with various ambassadors and partners to raise awareness and raise funds for Foundation initiatives.
Although she cannot travel due to her health issues, it is reported that Prince Albert and their children will soon be returning to South Africa to support her.
Charlene grew up in South Africa, also representing the country in swimming at the Sydney Olympics in 2000.
She had previously established the Princess Charlene of Monaco Foundation in South Africa to help save rhinos from poachers, but wanted to go to Thanda Safari in KwaZulu-Natal to find out more about what was being done.
It is not known at this time what medical procedures she is undergoing.